Search results for "Target organ"
showing 10 items of 31 documents
Glutathione levels in blood from ataxia telangiectasia patients suggest in vivo adaptive mechanisms to oxidative stress
2007
Objective: To evaluate an in vivo pro-oxidant state in patients with ataxia telangiectasia (AT). Methods: A set of oxidative stress endpoints were measured in 9 AT homozygotes, 16 AT heterozygotes (parents) and 83 controls (grouped in age ranges as for patients and parents, respectively). The following analytes were measured: (a) leukocyte 8-hydroxy-2-deoxyguanosine (8-OHdG); (b) blood glutathione (GSSG and GSH); and (c) plasma levels of glyoxal (Glx) and methylglyoxal (MGlx). Results: AT patients displayed a significant decrease in blood GSSG (p=0.012) and in MGlx plasma concentrations (P=0.012). A nonsignificant decrease in the GSSG:GSH ratio (p = 0.1) and a non-significant increase in 8-…
Value of Home Blood Pressures as Predictor of Target Organ Damage in Mild Arterial Hypertension
2002
Home blood pressure measurement has gained increasing importance for the management of hypertensive patients. The aim of our study was to compare levels of clinic (CBP), ambulatory (ABP), and home blood pressure (HBP) measurements, and their relationships with various indexes of target organ damage in I-II grade essential hypertension.Thirty-eight essential hypertensives underwent evaluation of clinic, ambulatory and home blood pressures. Each patient recorded HBP for 2 days with a digital BP monitor three times daily, the first time on the same day during which ABP monitoring was simultaneously performed. Moreover, in all subjects electrocardiogram recording, echocardiographic study, micro…
Influence of metabolic syndrome on hypertension-related target organ damage
2005
MuleG, Nardi E, Cottone S, Cusimano P, Volpe V, Piazza G, MongioviR, Mezzatesta G, Andronico G, Cerasola G (Universitadi Palermo, Palermo, Italy). Influence of metabolic syndrome on hypertension-related target organ damage. J Intern Med 2005; 257: 503-513. Objectives. The aim of our study was to analyse, in a wide group of essential hypertensive patients without diabetes mellitus, the influence of metabolic syndrome (MS) (defined according to the criteria laid down in the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults) on markers of preclinical cardiac, renal and retinal damage. Design. Cros…
Metabolic syndrome in hypertensive patients: An unholy alliance
2014
For many years, it has been recognized that hypertension tends to cluster with various anthropometric and metabolic abnormalities including abdominal obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, glucose intolerance, insulin resistance and hyperuricemia. This constellation of various conditions has been transformed from a pathophysiological concept to a clinical entity, which has been defined metabolic syndrome (MetS). The consequences of the MetS have been difficult to assess without commonly accepted criteria to diagnose it. For this reason, on 2009 the International Diabetes Federation, the American Heart Association and other scientific organizations pro…
The Relationship Between Aortic Root Size and Hypertension: An Unsolved Conundrum
2017
Thoracic aortic aneurysms rupture and dissection are among the most devastating vascular diseases, being characterized by elevated mortality, despite improvements in diagnostic imaging and surgical techniques. An increased aortic root diameter (ARD) represents the main risk factor for thoracic aortic dissection and rupture and for aortic valve regurgitation. Even though arterial hypertension is commonly regarded as a predisposing condition for the development of thoracic aorta aneurysms, the role of blood pressure (BP) as determinant of aortic root enlargement is still controversial. The use of different methods for indexation of ARD may have in part contributed to the heterogeneous finding…
Average real variability of 24-h systolic blood pressure is associated with microalbuminuria in patients with primary hypertension.
2015
Limited and conflicting data are available about the association between short-term blood pressure (BP) variability and urinary albumin excretion rate (uAER). The objective of our study was to analyze the relationships between microalbuminuria (MAU), defined as an uAER between 20 and 200 μg min(-1), and short-term BP variability (BPV), assessed as average real variability (ARV), weighted s.d. of 24-h BP and as s.d. of daytime and night-time BP. The study population consisted of 315 untreated essential hypertensives with normal estimated glomerular filtration rate (>60 ml min(-1) per 1.73 m(2)), who underwent 24-h ambulatory BP monitoring and 24-h uAER determination. MAU was detected in 82 (…
Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?
2021
Abstract It has long been known that blood pressure (BP) is characterized by marked short‐term fluctuations occurring within a 24‐h period and also by long‐term oscillations occurring over more prolonged periods of time. An increased short‐term blood pressure variability (BPV) appears to importantly contribute to target organ damage and to the enhanced cardiovascular risk of hypertensive patients, over and above the effect of an increase in mean BP levels. Reducing 24‐h mean BP is the main aim of antihypertensive therapy, but initial data are available that additional cardiovascular protection can be achieved by reducing BPV. However, to definitively prove the prognostic role of short‐term …
Imaging of non-glandular superficial metastases: A comparison of xeroradiography, ultrasonography and computed tomography
1989
Between January 1983 and July 1987, 1,622 cancer patients were evaluated to outline the possible applications and limits of various investigative techniques for evaluating metastases. Seventy-three cases with superficial metastases of the dermal-hypodermal (59) layers, of the muscles (11) and of other target organs (3) were included in the study. Although non-glandular superficial metastases are a relatively rare occurrence, diagnostic imaging techniques are indicated for evaluating their extent and anatomical connections. Secondary neoplasms were studied using the imaging techniques of sonography, computed tomography and xeroradiography. The diagnostic reliability of these three techniques…
Morphological abnormalities induced by Fenoxycarb on the pupa ofPhanerotoma (Phanerotoma) ocularisKohl (Hym., Braconidae)
1993
Fenoxycarb at concentrations of 0.001 μg/ml, 0.005 μg/ml, 0.01 μg/ml, 0.05μg/ml and 0.1 μg/ml had an adverse effect on the pupa of Phanerotoma (Phanerotoma) ocularis. When topically applied, it induced morphological abnormalities. The percentage of anomalous obtained depended of developmental pupal stage and was higher when was applied in the first moment of development (80 %-90 %) than in the final of development (50%-60%). These anomalous was inviables. Zusammenfassung Morphologische Abnormitaten bei Puppen von Phanerotoma (Phanerotoma) ocularis Kohl (Hym., Braconidae) nach Einwirkung von Fenoxycarb Fenoxycarb, in Konzentrationen von 0.001 μg/ml, 0.0005 μg/ml, 0.01 μg/ml, 0.05 |μg/ml und …
Physiological Effects of Thiobencarb Stress in the Eel (<i>Anguilla anguilla</i>)
2002
ヨーロッパウナギ Anguilla anguilla の代謝系へのチオベンカルブの影響と, 中毒からの回復とを評価した. 暴露期間ならびにそれに続く非汚染水中での8日間のウナギの血漿, 筋肉, 肝臓についてグリコーゲン, 脂質およびタンパクを測定した. 暴露により血糖値の上昇が認められたが, 肝臓と筋肉におけるグリコーゲンレベルは著しく低下した. 血中の脂質は増加したが, 肝臓での脂質は顕著に減少した. タンパク質の易動化は, とくに筋肉組織で認められた. ほとんどの代謝障害は, 非汚染水へ移した8日後まで継続した. 以上のチオベンカルブの代謝系への影響はある種のストレス症状であり, 魚類の農薬ストレスを代償しようとする生理的適応の具体例と考えられた.